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KMID : 1216720110030010017
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Korean Journal of Gynecologic Endocrinology
2011 Volume.3 No. 1 p.17 ~ p.23
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Adept® and Its Effects on the Inflammatory Response after Laparoscopic Gynecologic Surgery
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Park So-Young
Kim Heung-Yeol
Choi Young-Hwa
Choi Ji-Hyun
Jung Hyuk
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Abstract
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Objectives: Adhesions resulting from surgery are the most significant iatrogenic factor contributing to postoperative
infertility and pelvic pain. Adhesion prevention barriers are commonly used to mechanically separate opposing surfaces
during tissue healing. In general, the postoperative peritoneal cavity is an inflammatory environment. This
study investigated whether Adept® would enhance the postoperative inflammatory reaction or immune response to
foreign materials when left in the pelvic cavity.
Methods: This prospective study included 240 patients who underwent laparoscopic surgery in the Department of
Obstetrics and Gynecology, Chosun University Hospital from January 2009 through August 2010. Of the 196 patients
studied, 98 patients underwent laparoscopic surgery followed by application of Adept® (Group 1, Treatment)
and 98 patients underwent laparoscopic surgery without Adept® (Group 2, Control). Blood was collected to quantify
WBCs (white blood cells), ESR (erythrocyte sedimentation rate) and CRP (C-reactive protein) concentrations. In addition,
body temperature was measured before operation (Day 0) and at the 4th, 10th, and 21st days after operation.
Results: The two groups did not show any significant differences in medical examination prior to operation. The
same surgical methodology was employed during the surgical procedures of the two groups. There were no significant
differences in hematological findings, clinical symptoms, or body temperature at anytime following surgery
(P>0.05).
Conclusion: We found that the use of Adept® do not elicit an inflammatory reaction through laboratory finding and
clinical finding although it remains foreign material after laparoscopic surgery. So, we can use Adept® for preventing
adhesion safely.
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KEYWORD
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Adept®, Adhesion, Antiadhesion agent, Gynecologic laparoscopy, Inflammation reaction
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